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Styrene maleic anhydride (SMA) polymers are well suitable to solubilize and purifiy membrane proteins and their bound lipids directly from biological membranes without the need for conventional detergents. The resulting SMALPs with your target membrane protein are compatible with mainstream purification methods, allow you to perform functional assays, and are excellent platforms for Cryo-EM analysis.
The statistical distribution of styrene and maleic anhydride monomers lead to an optimal balance in polymer properties for high performance membrane protein extraction and stabilization.
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Three types of SMA products are available. These have been widely used in the SMALP research field for solubilization purification of membrane proteins along with bound lipids and partner proteins. The SMALP 30010 P is in general most recommended.